Born at Tsax̱is (Fort Rupert), Charles James Nowell was the first full blooded Kwakwaka'wakw to act as an interpreter and collector for outsiders. He was married to the daughter of Chief Lageuse of the 'Namgis First Nation. Between 1899 and his death in 1924, Nowell was the assistant to Charles F. Newcombe, an Englishman who supplied ethnographic objects to the Field Museum, the University of Pennsylvania Museum, the Peabody Museum at Harvard and others. Nowell and Bob Harris, also from Tsaxis, were part of the Kwakiutl and Nootka display at the 1904 St. Louis Universal Exposition.

Billy Assu (Kwakwaka'wakw) became Chief of the Cape Mudge (now We Wai Kai) First Nation in 1891 when he was 24 years old. He built the first modern house in the village in 1894 and during the 1920s organized the replacement of all the traditional longhouses with modern housing. He was a fisher for most of his life, and bought the first gas fish boat at Cape Mudge. During the Depression, he helped to create the Pacific Coast Native Fishermen's Association, which later merged with the Native Brotherhood of BC. His son, Harry Assu, succeeded him as the first elected Chief of the Cape Mudge band (1954-70).

Chief Thomas Hunt, was a singer, orator, and hereditary Chief of the Kwagulth Band of the Kwakwaka'wakw Nation. He was married to Emma (nee Billy) Hunt (Maxwalaogwa), the daughter of Mowachaht Chief and Shaman, Dr. Billy from Yuquot, Friendly Cove. Emma was an instructor of Kwagulth and Nuu-chah-nulth culture. Their children are: Ross Hunt Sr., Calvin Hunt, Tony Hunt, and Eugene Hunt and his grandfather was the renowned carver Mungo Martin.

Chief of the Musgamagw Dzawada'enuxw (Tsawataineuk) First Nation. Brother of Chief Peter Scow and Chief John Scow.

The Kyuquot Elementary School, currently (2019) known as Kyuquot Elementary Secondary School, is located on Vancouver Island. The school provides aboriginal education to students grades K-12. The school is a part of the Vancouver Island West School District 084 that includes other four First Nations Schools.